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ea0086p211 | Metabolism, Obesity and Diabetes | SFEBES2022

Investigating the effect of obesity on gut damage, systemic inflammation, enhanced asthma severity due to gut derived bacteria, endotoxin

Parenti Cristina , Murphy Alice M. , Lad Nikita , McTernan Philip G. , Nelson Carl P. , Sharpe Graham R. , Barber Claire , Abadalkareem Rana , Azim Adnan , Kurukulaaratchy Ramesh J. , Haitchi Hans M. , Williams Neil C.

Background: Obesity exacerbates a number of chronic inflammatory diseases including asthma, with increasing adiposity observed to worsen asthma severity and disease control. This exacerbation may arise as gut-derived bacterial fragments (endotoxin) and associated markers of endotoxin (lipopolysaccharide binding protein (LPB)), enter the circulation through a damaged gut barrier, provoking systemic inflammation. This study investigated the role of body weight on gut permeabilit...

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Investigating the effect of obesity on gut damage, systemic inflammation, enhanced asthma severity due to gut derived bacteria, endotoxin

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